About this project

Many complex diseases, such as rheumatoid arthritis, multiple sclerosis, asthma and Crohn’s Disease, are maintained by the ability of multiple cell types to freely communicate across the body. Since these cell populations are scattered between different locations, they can be difficult to target using a single drug. Consequently, managing these diseases often requires long term combination therapies. However, if we could re-route the cell-cell communication network underlying the disease, we could either skew it to a desired course or potentially alleviate it. Here we propose to do this using a unique technology: "nano-routers", programmable nanoscale robots, built from DNA, for the logical manipulation of cell-cell communication.